Major Incidents regularly occur in all countries and require well rehearsed responses to manage them succesfully. The medical response involves a wide range of acute care specialties including prehospital care, emergency medicine, surgery, theatres, anaesthesia and intensive care. This conference addresses the threat in Europe, informs from lessons learnt in the past and provides practical solutions to dilemmas faced by frontline staff. The speakers chosen have unique experience and pedigree in their chosen fields.